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If you're relying on commodities trading for income then getting the upgraded trade port to ship goods by sea and rail should be a priority.
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Ensure that roads where delivery vehicles interact with other city traffic is kept to a minimum. Where possible keep specialization chains together, like storage depots, mines, factories etc. event centers, universities, tourist attractions, high density factories etc). Spread out buildings that generate heavy traffic (i.e. Not zoning areas along the main exit route will help reduce congestion. I would also recommend not bringing streetcar avenues right up to the highway connection because it also puts an additional junction close to the busy exit. Avoiding 4 way junctions is a good strategy in general, but particularly on the connection to the region. Regardless of the arrangement of the highway exits in your city, you can reduce congestion by increasing the distance between the exit and the first junction. Getting the most out of your road network starts with dealing with the connection to the highway.
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Planning for Avenues in Early City Development.The following sections can be found in this article: This topic was originally designed to be much longer with examples of different basic road patterns etc, but to be honest I really couldn't find any that really worked with city-sized populations!
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